1H-Benzimidazole-6-carboxylic acid, 2-(chloromethyl)-1-[(2S)-2-oxetanylmethyl]-, methyl ester
Methyl (S)-2-(Chloromethyl)-1-(2-oxetanylmethyl)-1H-benzo[d]imidazole-6-carboxylate
CAS: 2230200-76-5
Molecular Formula: C14H15ClN2O3
1H-Benzimidazole-6-carboxylic acid, 2-(chloromethyl)-1-[(2S)-2-oxetanylmethyl]-, methyl ester - Names and Identifiers
1H-Benzimidazole-6-carboxylic acid, 2-(chloromethyl)-1-[(2S)-2-oxetanylmethyl]-, methyl ester - Physico-chemical Properties
| Molecular Formula | C14H15ClN2O3 |
| Molar Mass | 294.73 |
| Use | (S)-2-(chloromethyl)-1-(2-oxetylmethyl)-1H-benzo [D] imidazol-6-methyl formate is an organic carboxylate that can be used as a pharmaceutical intermediate. |
1H-Benzimidazole-6-carboxylic acid, 2-(chloromethyl)-1-[(2S)-2-oxetanylmethyl]-, methyl ester - Introduction
The Methyl (S)-2-(chlorometyl)-1-(2-oxetanylmethyl)-1H-benzo[d]imidazole-6-carboxylate is a chemical compound with the following properties:
1. Appearance: colorless or light yellow liquid or solid
2. Molecular formula: C17H16ClNO3
3. Molecular weight: 325.78g/mol
4. Melting Point: 72-75 ° C
5. Boiling point: 456.6 ° C
6. Density: 1.26 g/cm
7. Solubility: Soluble in general organic solvents, such as ethanol, dimethylformamide, etc.
The main use of this compound is as an intermediate in organic synthesis, commonly used in the synthesis of drugs, dyes, coordination compounds, etc. It has a high stereoselectivity, so it has a wide range of applications in Chiral synthesis.
Its preparation method can be achieved through the following steps:
1. (2-oxetanyl methyl)-1H-benzo [D] imidazole -6-carboxylic acid methyl ester and chloroform reaction to generate the corresponding acid chloride.
2. Methyl chloride was added to the acid chloride with the addition of cuprous bromide chloride catalyst, resulting in the chloro derivative of methyl (2-oxetanylmethyl)-1H-benzo [D] imidazole-6-carboxylate.
3. The chloro derivative is reacted with (-)-methyl 2-butyl ether for methyl acetone in the presence of potassium carbonate in an ammonia atmosphere at low temperature to generate the target compound.
Note the following safety information during use, preparation and storage:
1. The compound is irritating and corrosive, and personal protective equipment should be used when in contact with skin, eyes and mucous membranes.
2. Avoid inhalation or ingestion. If you accidentally come into contact with the skin or enter the body, you should immediately rinse with plenty of water and seek medical treatment in time.
3. During the preparation and storage process, avoid fire and heat sources to avoid fire or explosion.
4. Storage should be sealed, away from oxidants and acids.
5. Conduct regular safety inspections to ensure the integrity of the storage container and dispose of it in accordance with relevant regulations.
1. Appearance: colorless or light yellow liquid or solid
2. Molecular formula: C17H16ClNO3
3. Molecular weight: 325.78g/mol
4. Melting Point: 72-75 ° C
5. Boiling point: 456.6 ° C
6. Density: 1.26 g/cm
7. Solubility: Soluble in general organic solvents, such as ethanol, dimethylformamide, etc.
The main use of this compound is as an intermediate in organic synthesis, commonly used in the synthesis of drugs, dyes, coordination compounds, etc. It has a high stereoselectivity, so it has a wide range of applications in Chiral synthesis.
Its preparation method can be achieved through the following steps:
1. (2-oxetanyl methyl)-1H-benzo [D] imidazole -6-carboxylic acid methyl ester and chloroform reaction to generate the corresponding acid chloride.
2. Methyl chloride was added to the acid chloride with the addition of cuprous bromide chloride catalyst, resulting in the chloro derivative of methyl (2-oxetanylmethyl)-1H-benzo [D] imidazole-6-carboxylate.
3. The chloro derivative is reacted with (-)-methyl 2-butyl ether for methyl acetone in the presence of potassium carbonate in an ammonia atmosphere at low temperature to generate the target compound.
Note the following safety information during use, preparation and storage:
1. The compound is irritating and corrosive, and personal protective equipment should be used when in contact with skin, eyes and mucous membranes.
2. Avoid inhalation or ingestion. If you accidentally come into contact with the skin or enter the body, you should immediately rinse with plenty of water and seek medical treatment in time.
3. During the preparation and storage process, avoid fire and heat sources to avoid fire or explosion.
4. Storage should be sealed, away from oxidants and acids.
5. Conduct regular safety inspections to ensure the integrity of the storage container and dispose of it in accordance with relevant regulations.
Last Update：2024-04-09 20:49:11
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Product Name: Methyl (S)-2-(Chloromethyl)-1-(2-oxetanylmethyl)-1H-benzo[d]imidazole-6-carboxylate Request for quotationCAS: 2230200-76-5
Tel: +86-512-63001269
Email: sales@biosyntech-suzhou.com
sales1@biosyntech-suzhou.com
Mobile: +86-13921151340
QQ: 568471610
Wechat: biosyntech2019
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